Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a Senior Staff Digital Platform Engineer to help build and scale the common digital platform, engineering practices, and enablement model that allow teams across Information Sciences, R&D, and business functions to create trusted digital applications faster and more consistently. This role focuses on scaling how digital products are built across the enterprise. You will work with the other Staff Engineers to develop digital products, design reusable platform capabilities, shared services, reference architectures, engineering standards, and developer enablement programs that help domain teams build applications on top of RevMed's data and AI platform. You will also establish trustworthy patterns for AI-native and agentic engineering so AI-assisted and agent-based applications are secure, reliable, auditable, maintainable, and production-ready.

This is a cross-functional technical leadership role, partnering with Information Sciences, R&D, Data Product Management, Data Engineering, Platform Engineering, Security and business stakeholders.

Key Responsibilities

Build and Scale Digital Platform Capabilities

Design reusable platform capabilities, shared services, components, application templates, reference implementations, and golden path patterns for digital product development.
Define architecture patterns for backend services, APIs, frontend applications, workflow orchestration, data access, identity/access management, auditability, observability, and deployment.
Partner with platform, cloud, security, and architecture teams to ensure digital applications are secure, scalable, maintainable, and aligned with enterprise standards.
Standardize common patterns for authentication, authorization, logging, monitoring, notifications, workflow services, data access, environment management, and CI/CD.
Build communities of practice around modern software engineering, AI-native development, domain-driven design, test-driven development, and platform usage.
Establish Trustworthy AI and Agentic Engineering Practices
Define standards and guardrails for AI-assisted and agentic application development.
Create reusable patterns for RAG, LLM integration, agent workflow orchestration, prompt/tool design, validation workflows, human review, evaluation harnesses, telemetry, and AI observability.
Establish quality gates for AI-assisted software, including automated testing, code review, security checks, architectural review, observability, and production-readiness requirements.
Partner with Security, Privacy, QA/Validation, Architecture, and Information Sciences to define appropriate controls for regulated or sensitive workflows.

Shape the Digital Engineering Operating Model

Help define how central platform teams and domain delivery teams collaborate effectively.
Establish lightweight governance through architecture reviews, reusable templates, engineering checklists, design patterns, and production-readiness criteria.
Create onboarding materials, documentation, technical playbooks, starter kits, training paths, reusable examples, and design review practices.
Provide hands-on coaching, office hours, design reviews, and practical guidance to improve developer experience and platform adoption.
Mentor senior engineers and technical leads across Information Sciences and business domains.
Enable Information Sciences and R&D to build digital applications on top of the common platform.
Influence across teams by creating useful standards, practical tools, strong partnerships, and measurable outcomes.

First-Year Outcomes

The successful candidate will contribute to several of the following outcomes during the first 12 months:

Develop new digital products that will serve as digital platform reference architecture for future applications built on RevMed's data and AI platform.
Deliver initial golden paths for digital application development, including templates, deployment patterns, CI/CD pipelines, observability standards, and security-by-design controls.
Build or coordinate reusable shared services such as auth patterns, audit logging, notifications, workflow orchestration, data access APIs, UI components, telemetry, and environment templates.
Establish a practical agentic engineering framework covering guardrails, validation, evaluation, human-in-the-loop review, test automation, prompt/tool design, and production readiness.
Co-deliver one or more high-impact digital product reference implementations with Information Sciences, R&D, or business teams.
Define repeatable patterns for applications that consume governed data products through APIs, services, semantic layers, or workflow integrations.
Introduce API-first, domain-driven design and automated quality practices across digital product teams.
Define metrics for platform adoption, reuse, engineering quality, delivery speed, production reliability, and developer experience.
Reduce one-off application development through shared services, standard patterns, and reusable components.

Required Skills, Experience and Education:

12 - 15+ years of experience in software engineering, digital product engineering, platform engineering, enterprise architecture, or related technical roles.
Bachelor's degree in Computer Science, Engineering, Information Systems, or a related field, or equivalent professional experience.
Experience operating at a Senior Staff, Principal Engineer, Architect, Associate Director, Engineering Director or equivalent technical leadership level.
Proven experience designing and delivering production-grade digital applications, developer platforms, shared services, or reusable engineering frameworks.
Strong hands-on engineering background across backend services, APIs, distributed systems, cloud-native architectures, and modern frontend patterns.
Experience building or enabling full-stack digital products that integrate data, workflow, AI/GenAI, APIs, and user-facing interfaces.
Practical experience with AI-native application patterns such as RAG, LLM integration, agent orchestration, workflow automation, validation pipelines, and human-in-the-loop systems.
Strong understanding of platform engineering concepts, including golden paths, self-service capabilities, reusable components, developer experience, paved roads, and automated guardrails.
Experience defining architecture standards, system design patterns, and engineering practices adopted by multiple teams.
Knowledge of domain-driven design, test-driven development, automated testing, CI/CD, production readiness, observability, and secure SDLC.
Experience with AWS and/or Azure.
Ability to collaborate with Information Sciences, R&D, business stakeholders, Security, Architecture, Data Engineering, Platform Engineering, and Product Management.

Preferred Skills:

Experience in biotechnology, pharmaceutical R&D, life sciences, clinical development, regulatory, medical writing, or another regulated environment.
Experience building platforms or applications for scientific, research, clinical, regulatory, or enterprise business teams.
Experience with Databricks, Spark, Delta Lake, dbt, lakehouse architectures, vector databases, embeddings, feature stores, or semantic layers.
Experience with API management, event-driven architecture, workflow orchestration, data integration, and enterprise interoperability.
Experience establishing developer enablement programs, internal platforms, engineering academies, communities of practice, or technical coaching models.
Experience mentoring senior engineers, leading architecture forums, or defining standards across multiple teams.

#LI-YG1 #LI-Hybrid

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range

$186,000—$233,000 USD

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Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.

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